Association of CASP3 and CASP9 polymorphisms with genetic susceptibility to stomach cancer

• Published in: Zhonghua yi xue yi chuan xue za zhi Vol. 28; no. 3; p. 318
• Main Authors: Ni, Qin, Jiang, Xia, Jin, Ming-juan, Liu, Bing, Chen, Kun
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2011
• Subjects: Aged; Case-Control Studies; Caspase 3 - genetics; Caspase 9 - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Stomach Neoplasms - enzymology; Stomach Neoplasms - genetics
• ISSN: 1003-9406
• DOI: 10.3760/cma.j.issn.1003-9406.2011.03.018

To investigate the association between the apoptosis genes CASP3(rs12108497) and CASP9 (rs4646018) polymorphisms and the risk of developing stomach cancer. In this population-based case-controlstudy, 278 cases with stomach cancer and 278 age (± 5 years), gender, and residential area matched controls were recruited. The genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The unconditional Logistic regression analysis was utilized to calculate the odds ratios (OR) and 95% confidence intervals (CI). The individuals with TC, CC genotypes of rs12108497 locus had significantly increased risk of stomach cancer in comparison to those carrying TT genotype (OR= 1.45, 95% CI: 1.01-2.07 for TC; OR= 2.17, 95%CI: 1.15-4.08 for CC). However, the rs4646018 locus of CASP9 gene polymorphism was not related to stomach cancer risk. Compared with the subjects carrying the both low-risk genotypes, those carrying 1 or 2 high-risk genotypes had a noteworthy increased risk