Fluorescence analysis of the action of soluble derivatives of fullerene C60 on amyloid fibrils of the brain peptide Abeta(1-42)

It has been shown by fluorescence analysis in vitro that the water-soluble sodium salt of the polycarboxylic derivative of fullerene C60, fullerenol, and complexes of fullerene C60 with polyvinylpyrrolidone (mol. wt. 25000 and 10000) destroy amyloid fibrils of the brain peptide Abeta(1-42) and preve...

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Bibliographic Details
Published inBiofizika Vol. 55; no. 5; p. 780
Main Authors Bobylev, A G, Marsagishvili, L G, Podlubnaia, Z A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2010
Subjects
Amyloid - chemistry
Amyloid beta-Peptides - chemistry
Brain Chemistry
Fluorometry
Fullerenes - chemistry
Peptide Fragments - chemistry
Solubility
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Summary:It has been shown by fluorescence analysis in vitro that the water-soluble sodium salt of the polycarboxylic derivative of fullerene C60, fullerenol, and complexes of fullerene C60 with polyvinylpyrrolidone (mol. wt. 25000 and 10000) destroy amyloid fibrils of the brain peptide Abeta(1-42) and prevent their formation. The results of fluorescence analysis confirmed the data obtained earlier by high-resolution electron microscopy. Fluorescence analysis and electron microscopy are complementary methods for the selection of effective antiamylod drugs.
ISSN:0006-3029