Synthesis, crystal structure and living cell imaging of a Cu(2+)-specific molecular probe

We report the development of a rhodamine chromene-based fluorescence probe to monitor the intracellular Cu(2+) level in living cells. The new fluorescent probe exhibits a fluorescence response towards Cu(2+) under physiological conditions with high sensitivity and selectivity, and facilitates the na...

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Published inOrganic & biomolecular chemistry Vol. 9; no. 13; pp. 4802 - 4805
Main Authors Liu, Wei-Yong, Li, Hai-Ying, Zhao, Bao-Xiang, Miao, Jun-Ying
Format Journal Article
LanguageEnglish
Published England 07.07.2011
Subjects
Cations, Divalent - chemistry
Cell Survival
Copper - analysis
Copper - chemistry
Crystallography, X-Ray
Fluorescent Dyes - analysis
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Models, Molecular
Molecular Structure
Spiro Compounds - analysis
Spiro Compounds - chemistry
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Summary:We report the development of a rhodamine chromene-based fluorescence probe to monitor the intracellular Cu(2+) level in living cells. The new fluorescent probe exhibits a fluorescence response towards Cu(2+) under physiological conditions with high sensitivity and selectivity, and facilitates the naked-eye detection of Cu(2+). The fluorescence intensity was significantly increased by about 40-fold with 10 equiv. of added Cu(2+).
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ISSN:1477-0539
DOI:10.1039/c1ob05358b