The use of the deuterated internal standard for morphine quantitation for the purpose of doping control by gas chromatography with mass-selective detection

The objective of this study was to demonstrate the possibility to use deuterated compounds as internal standards for the quantitative analysis of morphine by gas chromatography with mass-selective detection for the purpose of doping control. The paper is focused on the problems associated with the u...

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Bibliographic Details
Published inSudebno-meditsinskaia ekspertiza Vol. 53; no. 3; p. 29
Main Authors Savel'eva, N B, Bykovskaia, N Iu, Dikunets, M A, Bolotov, S L, Rodchenkov, G M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.2010
Subjects
Analgesics, Opioid - analysis
Deuterium - analysis
Deuterium - chemistry
Doping in Sports - prevention & control
Gas Chromatography-Mass Spectrometry - methods
Humans
Morphine - analysis
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Summary:The objective of this study was to demonstrate the possibility to use deuterated compounds as internal standards for the quantitative analysis of morphine by gas chromatography with mass-selective detection for the purpose of doping control. The paper is focused on the problems associated with the use of deuterated morphine-D3 as the internal standard. Quantitative characteristics of the calibration dependence thus documented are presented along with uncertainty values obtained in the measurements with the use of deuterated morphine-D6. An approach to the assessment of method bias associated with the application of morphine-D6 as the deuterated internal standard is described.
ISSN:0039-4521