Tumor necrosis factor-alpha gene G308A polymorphism is associated with the risk of preterm delivery

To investigate the association between polymorphism in tumor necrosis factor-alpha(TNF-alpha)/G308A and preterm delivery (PTD). Between July 1999 and June 2001, we conducted a molecular epidemiological study on genetic determinants of PTD at Anqing Hospital, China. In a case-control-parent triads st...

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Bibliographic Details
Published inBeijing da xue xue bao. Journal of Peking University. Yi xue ban Vol. 35; no. 4; p. 377
Main Authors Chen, Dafang, Hu, Yonghua, Wu, Baiyan, Chen, Li, Fang, Zhi'an, Yang, Fan, Wang, Lihua
Format Journal Article
LanguageEnglish
Published China 01.08.2003
Subjects
Alleles
China
Female
Genotype
Humans
Infant, Newborn
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Pregnancy
Premature Birth - genetics
Risk Factors
Tumor Necrosis Factor-alpha - genetics
China
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Summary:To investigate the association between polymorphism in tumor necrosis factor-alpha(TNF-alpha)/G308A and preterm delivery (PTD). Between July 1999 and June 2001, we conducted a molecular epidemiological study on genetic determinants of PTD at Anqing Hospital, China. In a case-control-parent triads study, we investigated a total of 133 nuclear families: 79 normal gestational age families and 54 PTD families. A DNA extraction and polymerase chain reaction followed by restriction fragment length polymorphism analysis were used to genotype for the presence of TNF-alpha/G308A polymorphism. Gestational age was analyzed as a binary variable. Multiple logistic regression analysis results showed that TNF-alpha/A308A genotype was significantly increased the risk of preterm delivery (OR = 0.039, 95% CI: 1.14-128.75). In consistence with the population based multiple logistic regression analysis, Family Based Association Test (FBAT) analysis showed that TNF-alpha/308A allele was associated with preterm delivery as 308A-recessive inheritance model and 308A-additive inheritance model both gave rise to the significant result (P = 0.040 and P = 0.018 respectively). Carriage of the mutant 308A allele of TNF-alpha/G308A polymorphism is associated with preterm delivery, which may be genuine etiologic factors of PTD.
ISSN:1671-167X