Efficacy and safety of chemotherapy combined with interstitial (125)I seed implantation brachytherapy in unresectable stage IIIa/IIIb non-small cell lung cancer

• Published in: Zhōnghuá zhŏngliú zázhì Vol. 32; no. 8; p. 626
• Main Authors: Yang, Shu-fa, Fan, Xi-wen, Zhang, Guo-qing, Shan, Li
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2010
• Subjects: Alopecia - etiology; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Brachytherapy - adverse effects; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - radiotherapy; Cisplatin - administration & dosage; Combined Modality Therapy; Deoxycytidine - administration & dosage; Deoxycytidine - analogs & derivatives; Diarrhea - etiology; Female; Follow-Up Studies; Humans; Iodine Radioisotopes - adverse effects; Iodine Radioisotopes - therapeutic use; Leukopenia - etiology; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Lung Neoplasms - radiotherapy; Male; Middle Aged; Neoplasm Staging; Remission Induction; Survival Rate; Vinblastine - administration & dosage; Vinblastine - analogs & derivatives; Vomiting - etiology
• ISSN: 0253-3766

To compare the efficacy and toxicity of chemotherapy combined with insterstitial (125)I seed implantation brachytherapy in unresectable staged IIIa/IIIb non-small cell lung cancer. Seventy six patients with staged IIIa/IIIb non-small cell lung cancer were included in this study. Among them 37 cases were of the study group, treated with NP/GP scheme synchronization chemotherapy combined with (125)I seed implantation brachytherapy, while 39 cases in the control group were given NP/GP scheme chemotherapy. The cumulative survival time and median survival time of the two groups were compared by Kaplan-Meier analysis. The difference of mean survival time between the two groups was analyzed by log-rank method. The study group and the control group achieved a total response rate of 56.8% and 30.8%, local control rate of 78.4% and 56.4%, respectively, showing a statistically significant difference (P < 0.05). The 1-year survival rates of the study group and control group were 66.7% and 45.3%, and the median survival t