Correlation of polymorphism rs1563828 in MDM4 gene with breast cancer risk and onset age

• Published in: Chung-hua wai kʿo tsa chih Vol. 50; no. 1; p. 53
• Main Authors: Song, Chuan-gui, Fu, Fang-meng, Wu, Xue-ying, Wang, Chuan, Shao, Zhi-min
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2012
• Subjects: Adult; Age of Onset; Breast Neoplasms - epidemiology; Breast Neoplasms - genetics; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Logistic Models; Nuclear Proteins - genetics; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins - genetics; Risk Factors
• ISSN: 0529-5815

To explore effect of polymorphism rs1563828 (C > T) in human murine double minute 4 gene (MDM4) on genetic susceptibility for early-onset breast cancer and potential association with age of onset of breast cancer. One hundred and twenty-four early-onset breast cancer patients (age ≤ 35 years at time of diagnosis) from independent families admitted from January 2006 to June 2010 and 101 age-matched healthy control subjects were analyzed. Genotype analysis was conducted by polymerase chain reaction and then MALDI-TOF-MS assay. Association of genotype distribution and breast cancer risk was evaluated by χ(2) test. The odd-ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional Logistic regression model. The t test was used to compare the age and demographic differences among groups. The frequency of rs1563828 polymorphism genotypes in control group were CC 43.6% (44/101), CT 42.6% (43/101), TT 13.9% (14/101), and in case group were 42.7% (53/124), 46.0% (57/124), 11.3% (14/124), respective