Developmental regulation of long term potentiation at layer II/III to II/III synapses of rat visual cortex

In the present research, patch-clamp whole-cell recording was used to study the developmental changes of the internal horizontal synaptic plasticity in layer II/III of rats' primary visual cortices. Pairing stimulation was used to induce long term potentiation (LTP) of neurons in layer II/III f...

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Bibliographic Details
Published inSheng li hsüeh pao Vol. 61; no. 5; p. 458
Main Authors Jin, Zhou, Cai, Yi-Ping, Li, Dong-Sheng, Deng, Jian-Xin, Shi, Jian
Format Journal Article
LanguageChinese
Published China 25.10.2009
Subjects
Animals
Long-Term Potentiation
Neuronal Plasticity
Neurons - physiology
Patch-Clamp Techniques
Rats
Receptors, AMPA - physiology
Synapses - physiology
Visual Cortex - physiology
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Summary:In the present research, patch-clamp whole-cell recording was used to study the developmental changes of the internal horizontal synaptic plasticity in layer II/III of rats' primary visual cortices. Pairing stimulation was used to induce long term potentiation (LTP) of neurons in layer II/III from layer II/III and layer IV. The data indicate that: (1) Responses of layer II/III neurons can be evoked independently at II/III-II/III and IV-II/III synapses by horizontal and vertical stimulations; (2) LTP can be induced from neurons in the layer II/III by horizontal tetanic stimulation at II/III-II/III synapses till postnatal day12 (P12, before eyes open); (3) Meanwhile, only short term potentiation (STP) at IV-II/III synapses can be induced by horizontal tetanic stimulation before eyes open; (4) After P12, a robust LTP at IV-II/III synapses can be induced by horizontal tetanic stimulation; (5) At P14, when vertical and horizontal tetanic stimulations were given to the same neuron, the LTP at IV-II/III synapses was
ISSN:0371-0874