Study on the activated fraction with proliferation and apoptosis effect on T lymphocyte of Celastrus aculeatus

To screen the activated fraction from Celastrus aculeatus and study its effect on T lymphocyte apoptosis. Different polarity fractions were isolated from Celastrus aculeatus extract. Flow Cytometry method was used to detect apoptosis ratio of the active fractions. Different fractions extract from Ce...

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Bibliographic Details
Published inZhong yao cai Vol. 34; no. 8; p. 1237
Main Authors Chen, Pei-Hong, Ding, Zong-Bao, Xie, Yang, Tong, Li
Format Journal Article
LanguageChinese
Published China 01.08.2011
Subjects
Acetates - chemistry
Animals
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Apoptosis - drug effects
Celastrus - chemistry
Cell Proliferation - drug effects
Cells, Cultured
Female
Flow Cytometry
Male
Mice
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Solvents - chemistry
Spleen - cytology
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
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Summary:To screen the activated fraction from Celastrus aculeatus and study its effect on T lymphocyte apoptosis. Different polarity fractions were isolated from Celastrus aculeatus extract. Flow Cytometry method was used to detect apoptosis ratio of the active fractions. Different fractions extract from Celastrus aculeatus and GSF-A could significantly inhibit T lymphocyte proliferation and induce T lymphocyte apoptosis. The activated fractions isolated from Celastrus aculeatus have anti-inflammatory effect. Its mechanism may be related to the apoptosis effect on T lymphocyte.
ISSN:1001-4454