Preparation of superparamagnetic paclitaxel nanoparticles from modified chitosan and their cytotoxicity against malignant brain glioma

We synthesized the superparamagnetic paclitaxel nanoparticles from modified chitosan tangling around Fe3O4 ferrofluid and taxol, and observed the nanoparticles with transmission electronic microscopy (TEM). Then we evaluated the paramagnetism of the particles by vibration specimen magnetometer (VSM)...

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Published inSheng wu yi xue gong cheng xue za zhi Vol. 28; no. 3; p. 513
Main Authors Zhao, Ming, Li, Anmin, Chang, Jin, Wang, Hanjie, Liang, Shuli, Zhang, Jiajing, Yan, Runmin
Format Journal Article
LanguageChinese
Published China 01.06.2011
Subjects
Antineoplastic Agents, Phytogenic - pharmacology
Apoptosis - drug effects
Brain Neoplasms - pathology
Cell Line, Tumor
Chitosan - pharmacology
Drug Carriers - chemistry
Drug Compounding - methods
Ferric Compounds
Glioma - pathology
Humans
Magnetics
Metal Nanoparticles - chemistry
Nanoparticles
Paclitaxel - pharmacology
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Summary:We synthesized the superparamagnetic paclitaxel nanoparticles from modified chitosan tangling around Fe3O4 ferrofluid and taxol, and observed the nanoparticles with transmission electronic microscopy (TEM). Then we evaluated the paramagnetism of the particles by vibration specimen magnetometer (VSM) and tested their cytotoxicity with flow cytometry (FCM). The prepared nanoparticle solution was black without any floccule or sediment and appeared transparent after diluted. The nanoparticles were spherical and dispersed in water with mean diameter of 15 nm under TEM and showed superparamagnetic character. FCM test showed the nanoparticles had significant toxic effects against malignant astrocytoma U251 cell lines, equal to taxol alone. These results showed that the superparamagnetic nanoparticle not only enhanced the solubility of paclitaxel in water, but also was superparamagnetic and cytotoxic, which make suitable tools for magnetic targeting chemotherapy of brain gliomas.
ISSN:1001-5515