Clinicopathologic characteristics of breast cancer with basal-like immunophenotype

To study the clinicopathologic characteristics of basal-like immunophenotype breast cancer (BLBC). 458 cases of female infiltrative breast cancer were studied using immunohistochemical staining with an antibody panel of ER, PR, HER2, Ki-67, CK5/6, CK14 and epidermal growth factor receptor (EGFR) and...

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Bibliographic Details
Published inZhonghua bing li xue za zhi Vol. 37; no. 11; p. 743
Main Authors Wu, Wan-xin, Han, Wen-lan, Zhang, Yan-ping, Yu, Qi-xia, Wen, Xiao-wei, Lu, Ning, Tang, Zheng-ying, Yuan, Lin-na, Zhang, Yi, Wang, Zhen, Wang, Wei, Yang, Hong-jie, Chen, Cai-ping, Guo, Wen-li
Format Journal Article
LanguageChinese
Published China 01.11.2008
Subjects
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Biomarkers, Tumor - immunology
Breast Neoplasms - diagnosis
Breast Neoplasms - immunology
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Female
Humans
Immunophenotyping - methods
Middle Aged
Prognosis
Receptor, Epidermal Growth Factor - analysis
Receptor, Epidermal Growth Factor - immunology
Receptor, ErbB-2 - analysis
Receptor, ErbB-2 - immunology
Receptors, Estrogen - analysis
Receptors, Estrogen - immunology
Receptors, Progesterone - analysis
Receptors, Progesterone - immunology
Survival Rate
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Summary:To study the clinicopathologic characteristics of basal-like immunophenotype breast cancer (BLBC). 458 cases of female infiltrative breast cancer were studied using immunohistochemical staining with an antibody panel of ER, PR, HER2, Ki-67, CK5/6, CK14 and epidermal growth factor receptor (EGFR) and were classified basing on the immunophenotypes. The clinicopathologic characteristics were compared with other immunophenotypes of breast cancer. 228 of 458 cases of breast cancer were followed up. 46 cases of BLBC were screened out among the 458 breast cancers. And histological features of BLBC were analysed including the larger diameter of cancer foci (average 3.3 cm), appearance of squeezing phenomenon of neighboring cell borders (58.7%, 27/46), geography-like distribution of necrosis (52.2%, 24/46), central zone fibrosis (30.4%, 14/46) and lymphoplasmacytic infiltration at the margin and stroma (63.0%, 29/46). There were nuclear pleomorphism with numerous mitoses. The cancer cells were closely arranged, formin
ISSN:0529-5807