Study on the ultraviolet protective effects of the cream of the total flavonoids from Oxytropis falcata

• Published in: Zhong yao cai Vol. 34; no. 3; p. 415
• Main Authors: Li, Mao-Xing, Lan, Zhi-Hui, He, Xi-Rui, Zhang, Ru-Xue, Jia, Zheng-Ping, Du, Qing-Yun, Hong, Jia-Ni
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2011
• Subjects: Animals; Antioxidants - administration & dosage; Antioxidants - pharmacology; Body Weight - drug effects; Disease Models, Animal; Female; Flavonoids - pharmacology; Glutathione Peroxidase - metabolism; Glutathione Transferase - metabolism; Hydrogen Peroxide - metabolism; Malondialdehyde - metabolism; Oxidative Stress; Oxytropis - chemistry; Radiation-Protective Agents - pharmacology; Random Allocation; Rats; Rats, Wistar; Skin - drug effects; Skin - metabolism; Skin - pathology; Skin - radiation effects; Superoxide Dismutase - metabolism; Ultraviolet Rays - adverse effects
• ISSN: 1001-4454

To study the protective effects of the cream of the total flavonoids from Oxytropis falcata on the destructed skin of mice induced by moderate-wave ultraviolet (UVB) irradiation. Dorsal skin of Wistar mice were treated with the cream of the total flavonoids from Oxytropis falcata and then irradiated with UVB in the dosage of 5 min once a day for one week. The tissue of skin was pathological diagnosed and the activities or contents of superoxide dismutase (SOD), malondialdehyde (MDA), hydroxyproline (Hyp), glutathione peroxidease (GSH-Px), glutathione (GSH), glutathion-s-transferase (GST), catalase (CAT) and hydroxy radical (*OH) were determined with chromatometry. The ultraviolet protective effects of the cream could be observed with appearance and pathology examine. The cream could increase the activities of SOD (P < 0.001), GSH-Px (P < 0.001), GST (P < 0.05) and CAT (P < 0.01), raise the content of Hyp (P < 0.001) significantly. The cream could also decrease the contents of MDA and *OH (P < 0.001), and the