Late endothelial function in children with coronary aneurysm due to Kawasaki disease

To evaluate the late endothelial function in children with coronary aneurysm due to Kawasaki disease (KD). Thirty-one children with coronary aneurysms due to KD who had the disease course for more than 1 year and twenty-one age-matched healthy children were enrolled. Brachial artery endothelium-depe...

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Bibliographic Details
Published inZhongguo dang dai er ke za zhi Vol. 13; no. 5; p. 373
Main Authors Duan, Chao, DU, Zhong-Dong, Wang, Yu, Jia, Li-Qun
Format Journal Article
LanguageChinese
Published China 01.05.2011
Subjects
Adolescent
Child
Coronary Aneurysm - etiology
Coronary Aneurysm - physiopathology
Endothelium, Vascular - physiopathology
Female
Humans
Male
Mucocutaneous Lymph Node Syndrome - complications
Mucocutaneous Lymph Node Syndrome - physiopathology
Vasodilation
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Summary:To evaluate the late endothelial function in children with coronary aneurysm due to Kawasaki disease (KD). Thirty-one children with coronary aneurysms due to KD who had the disease course for more than 1 year and twenty-one age-matched healthy children were enrolled. Brachial artery endothelium-dependent and -independent flow-mediated dilation (FMD), carotid arterial stiffness index (SI) and intima-media thickness (IMT) were measured by high-frequency ultrasound. There were 9 cases of medium and 22 cases of giant coronary aneurysms in the KD group. Twelve KD patients had evidence of myocardial ischemia. Compared to the normal controls, the endothelium-dependent FMD decreased (P<0.05), the carotid arterial SI increased (P<0.05), and the carotid arterial intima-media thickness increased significantly (P<0.05) in children with coronary aneurysms due to KD. The endothelium-dependent FMD decreased more significantly in 12 KD patients with myocardial ischemia than in those without any evidence of myocardial ischemi
ISSN:1008-8830