Multidisciplinary treatment including pneumonectomy for squamous cell carcinoma of the anal canal-a case report

• Published in: Gan to kagaku ryoho Vol. 38; no. 12; p. 2277
• Main Authors: Aoyagi, Haruhiko, Kaneko, Jun, Kamiya, Ayako, Isogai, Jun, Iwata, Noriko, Katsuta, Eriko, Takahata, Taro, Hasegawa, Kumi, Teduka, Kenji, Higuchi, Tetsuro, Maejima, Shizuaki
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.11.2011
• Subjects: Anus Neoplasms - pathology; Anus Neoplasms - therapy; Carcinoma, Squamous Cell - therapy; Combined Modality Therapy; Female; Humans; Lung Neoplasms - secondary; Lung Neoplasms - surgery; Middle Aged; Neoplasm Staging; Pneumonectomy; Tomography, X-Ray Computed
• ISSN: 0385-0684

In August 2008, a 52-year-old woman presented to our hospital with a complaint of bleeding upon defecation. The patient underwent lower gastrointestinal endoscopy with biopsy. PRb indicated a type 2 lesion in one-third of the circumference. The patient was diagnosed with squamous cell carcinoma by biopsy. Imaging did not reveal any metastasis to other organs. In September, she underwent an abdominoperineal resection of the rectum. Postoperative histopathological findings were PRb, type 2, A, N3, H0, P0, M0, and Stage III b. Adjuvant chemotherapy of oral S-1 was started. In January 2009, contrast-enhanced abdominal CT revealed a pelvic recurrence, and the patient underwent chemoradiotherapy. In October, chest CT showed a 5-mm solitary pulmonary metastasis in the right apex of the lung. In March 2010, chest CT showed a slight enlargement of the tumor in the right apex, but no other metastatic lesion was observed. In April, the patient underwent a thoracoscopic partial pneumonectomy. It has been 16 months postoperatively, and no recurrence has been observed. In the present report, we describe a case of squamous cell carcinoma of the anal canal that underwent multidisciplinary treatment including pneumonectomy. We also include a brief literature review.