mFOLFOX6 for treatment of anal canal cancer with disseminated carcinomatosis of bone marrow--a case report

• Published in: Gan to kagaku ryoho Vol. 37; no. 11; p. 2209
• Main Authors: Yamauchi, Masami, Okamoto, Yohei, Doi, Mihoko, Shinozaki, Katsunori
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.11.2010
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - pathology; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Anus Neoplasms - drug therapy; Anus Neoplasms - pathology; Bone Marrow Neoplasms - drug therapy; Carcinoma - drug therapy; Disseminated Intravascular Coagulation - complications; Fluorouracil - therapeutic use; Humans; Leucovorin - therapeutic use; Male; Organoplatinum Compounds - therapeutic use
• ISSN: 0385-0684

A 66-year-old man was referred to our hospital because of a two-week history off ever and low back pain. There was a hard anal mass on rectal examination. Colonoscopy and computed tomography showed anal adenocarcinoma, multiple metastases to lymph nodes and bones. Blood test showed severe disseminated intravascular coagulation (DIC). Microscopic examination of the bone marrow aspirate revealed disseminated carcinomatosis of the bone marrow. Systemic chemotherapy (mFOLFOX6) was started, then remission of DIC and shrinkage of the tumor were observed. Although the patient had cerebral infarction during the first course of chemotherapy, he received nine courses of treatment. He died six months later because of cerebellar hemorrhage.