mFOLFOX6 for treatment of anal canal cancer with disseminated carcinomatosis of bone marrow--a case report

A 66-year-old man was referred to our hospital because of a two-week history off ever and low back pain. There was a hard anal mass on rectal examination. Colonoscopy and computed tomography showed anal adenocarcinoma, multiple metastases to lymph nodes and bones. Blood test showed severe disseminat...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 37; no. 11; p. 2209
Main Authors Yamauchi, Masami, Okamoto, Yohei, Doi, Mihoko, Shinozaki, Katsunori
Format Journal Article
LanguageJapanese
Published Japan 01.11.2010
Subjects
Adenocarcinoma - drug therapy
Adenocarcinoma - pathology
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Anus Neoplasms - drug therapy
Anus Neoplasms - pathology
Bone Marrow Neoplasms - drug therapy
Carcinoma - drug therapy
Disseminated Intravascular Coagulation - complications
Fluorouracil - therapeutic use
Humans
Leucovorin - therapeutic use
Male
Organoplatinum Compounds - therapeutic use
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Summary:A 66-year-old man was referred to our hospital because of a two-week history off ever and low back pain. There was a hard anal mass on rectal examination. Colonoscopy and computed tomography showed anal adenocarcinoma, multiple metastases to lymph nodes and bones. Blood test showed severe disseminated intravascular coagulation (DIC). Microscopic examination of the bone marrow aspirate revealed disseminated carcinomatosis of the bone marrow. Systemic chemotherapy (mFOLFOX6) was started, then remission of DIC and shrinkage of the tumor were observed. Although the patient had cerebral infarction during the first course of chemotherapy, he received nine courses of treatment. He died six months later because of cerebellar hemorrhage.
ISSN:0385-0684