Antioncogene PTEN-a new target for myeloma therapy

Pten gene is the first antioncogene with dual phosphatase activity discovered so far, pten gene regulates the cell cycle progress, apoptosis, metastasis and invasion of the tumor cells through negatively regulating the multiple signaling transduction pathways. Multiple myeloma (MM) is a malignant tu...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 18; no. 3; p. 816
Main Authors Wang, Su-Yun, Cheng, Zhi-Yong, Deng, Kai, Chen, Hao, Pan, Lin
Format Journal Article
LanguageChinese
Published China 01.06.2010
Subjects
Humans
Multiple Myeloma - metabolism
Multiple Myeloma - therapy
PTEN Phosphohydrolase - genetics
PTEN Phosphohydrolase - metabolism
Signal Transduction
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Summary:Pten gene is the first antioncogene with dual phosphatase activity discovered so far, pten gene regulates the cell cycle progress, apoptosis, metastasis and invasion of the tumor cells through negatively regulating the multiple signaling transduction pathways. Multiple myeloma (MM) is a malignant tumor occurring in terminal stage of B cell differentiation. The genetic changes are considered as the important factors in MM pathogenesis, among which the deletion of antioncogene is a critical genetic change. However, little is known about the genetic change of pten in MM. This review summarizes the research advance on pten in MM including structure of pten, mechanism of pten effect and correlation of pten with MM in order to provide some references for the investigating new gene target to treat the MM.
ISSN:1009-2137