Application of standardized uptake value for FDG PET-CT in predicting radiation pneumonitis

• Published in: Zhōnghuá zhŏngliú zázhì Vol. 31; no. 8; p. 622
• Main Authors: Zhang, Yong, Yu, Yong-hua, Yu, Jin-ming, He, Wei, Fu, Zheng, Guo, Shou-fang, Liu, Xi-jun, Cong, Chang-sheng
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2009
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung - radiotherapy; Female; Fluorodeoxyglucose F18 - pharmacokinetics; Follow-Up Studies; Humans; Lung Neoplasms - radiotherapy; Male; Middle Aged; Positron-Emission Tomography; Radiation Dosage; Radiation Pneumonitis - diagnosis; Radiation Pneumonitis - etiology; Radiation Pneumonitis - metabolism; Radiopharmaceuticals - pharmacokinetics; Radiotherapy, Conformal - adverse effects; Tomography, X-Ray Computed
• ISSN: 0253-3766

To investigate the correlation of radiation pneumonitis (RP) with standardized uptake value (SUV) for fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET-CT) in lung cancer patients treated with radiation therapy. Fourty patients with unresectable non-small cell lung cancer (NSCLC) received FDG PET-CT before and after radiotherapy. The average SUV of the lung tissue irradiated with a dose of < or = 5 Gy, 5.1 approximately 15 Gy, 15.1 approximately 35 Gy, 35.1 approximately 60 Gy, >60 Gy were measured. The correlation between SUV and RP was analyzed by comparing the SUV in the patients with RP and without. The SUV ratio of the irradiated lung tissue to that of the non-irradiated lung tissue (L/B) was also calculated. Of the 40 patients, 8 developed RP, including 6 cases of grade 2 and 2 cases of grade 3. The SUV of irradiated lung tissues with a dose of 35.1 approximately 60 Gy was significantly correlated with RP. When SUV > or =1, the RP incidence rate was 41.7% versus 20.0% in