Prevalence of high-risk human papillomavirus and incidence of cervical intraepithelial neoplasia in female populations in Shenzhen, Guangdong Province

• Published in: Zhōngguó yīxué kēxuéyuàn xuébào Vol. 32; no. 1; p. 90
• Main Authors: Wu, Rui-fang, Liu, Zhi-hua, Zhou, Qing-zhi, Wulan, Na, Wang, Qian, Li, Qing, Li, Ni, Liu, Zhi-hong, Shi, Jü-fang, Li, Rui-zhen, Zhang, Chang-huai, Zhou, Yan-qiu, Liu, Bin, Weng, Lei-ming, Qiao, You-lin
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2010
• Subjects: Adolescent; Adult; Cervical Intraepithelial Neoplasia - epidemiology; Chi-Square Distribution; China - epidemiology; DNA, Viral - isolation & purification; Female; Humans; Incidence; Mass Screening - methods; Middle Aged; Papillomaviridae - genetics; Papillomavirus Infections - epidemiology; Uterine Cervical Neoplasms - diagnosis; Young Adult; China
• ISSN: 1000-503X
• DOI: 10.3881/j.issn.1000-503X.2010.01.021

To investigate the prevalence of high-risk human papillomavirus (HPV) and incidence of cervical intraepithelial neoplasia (CIN) in female populations in Shenzhen, Guangdong Province, China. Totally 1137 women aged 15-59 from Shahe Community, Nanshan District, Shenzhen were investigated for cervical cancer during an population-based epidemiological screening from November 2004 to December 2004. Visual inspection with acetic acid (VIA), colposcopy, liquid-based cytology test (LCT), and hybrid capture 2 (HC-) were performed to detect the high-risk HPV types in cervical secretions. Biopsy under colposcope was performed in women who were HPV-positive with LCT >or= atypical squamous cells of undetermined sign (ASCUS) or HPV-negative with LCT >or= low grade squamous intraepithelial lesion (LSIL), with the pathological results as the golden standards. The detection rate of high-risk HPV-DNA was 14.0%. HPV detection rates in 15-24, 25-29, 30-34, 35-39, 40-44, 45-49, and 50-59 age groups were 15.5%, 17.7%, 12.6%, 8.8%,