Investigation of FLT3-ITD and NPM1 mutations in patients with myelodysplastic syndrome and mixed myeloid diseases

Two FLT3-ITD mutations, one FLT3-TKD) and five NPM1 mutations were detected in 7 patients with de novo myelodysplastic syndrome (MDS) out of 44 cases of MDS and MDS/mixed myeloid diseases. Expression of one of the three investigated mutations was identified: 4 in gene NPM1 (9.1%) and 2--FLT3-ITD (4....

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Published inVoprosy onkologij Vol. 56; no. 6; p. 671
Main Authors Gritsaev, S V, Martynkevich, I S, Ivanova, M P, Moskalenko, M V, Aksenova, V Iu, Tiranova, S A, Abdulkadyrov, K M
Format Journal Article
LanguageRussian
Published Russia (Federation) 2010
Subjects
Aged
Bone Marrow Diseases - genetics
Disease Progression
Female
fms-Like Tyrosine Kinase 3 - genetics
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Mutation
Myelodysplastic Syndromes - genetics
Nuclear Proteins - genetics
Predictive Value of Tests
Prognosis
Time Factors
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Summary:Two FLT3-ITD mutations, one FLT3-TKD) and five NPM1 mutations were detected in 7 patients with de novo myelodysplastic syndrome (MDS) out of 44 cases of MDS and MDS/mixed myeloid diseases. Expression of one of the three investigated mutations was identified: 4 in gene NPM1 (9.1%) and 2--FLT3-ITD (4.5%); simultaneous FLT3-ITD and NPM1 mutation--1 (2.3%); no progression in NPM1 within 9-20 months--3, although with chromosome 7 damage--2. It was suggested that NPM1 mutation without complex karyotype may serve as marker of relatively favorable course.
ISSN:0507-3758