Inhalation of aerosolized perfluorocarbon combined with tetramethylpyrazine ameliorates hemodynamics and pulmonary histopathology in a porcine model of acute lung injury

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 31; no. 8; p. 1382
• Main Authors: Peng, Xue-mei, Xie, Juan-hua, Shuai, Bing, Li, Yan-lan, Wang, Zhong-hong, Wang, Hua-dong, Wang, Yan-ping
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2011
• Subjects: Acute Lung Injury - drug therapy; Acute Lung Injury - etiology; Acute Lung Injury - pathology; Administration, Inhalation; Animals; Drug Therapy, Combination; Fluorocarbons - administration & dosage; Hemodynamics - drug effects; Lung - pathology; Phytotherapy; Pyrazines - administration & dosage; Swine
• ISSN: 1673-4254

To observe the effect of inhalation of aerosolized perfluorocarbon combined with tetramethylpyrazine on the hemodynamics and histopathology in a porcine model of acute lung injury. Normal adult pigs were subjected to saline lavage of the bilateral lungs to induce acute lung injury and randomized subsequently into 3 groups for treatment with inhalation of perfluorocarbon, combined inhalation of perfluorocarbon and tetramethylpyrazine, or inhalation of tetramethylpyrazine. The changes of mean arterial pressure (MAP), PetCO(2), mPAP, CVP and PAWP were recorded at different time points following the lung injury, and the lung tissues were sampled for histological observations. The MAP, mPAP, CVP and PAWP all increased significantly in the 3 groups after acute lung injury. Interventions with combined tetramethylpyrazine and perfluorocarbon inhalation significantly improved these indices as compared with inhalation of tetramethylpyrazine or perfluorocarbon alone (P<0.05). The pulmonary pathology was the mildest in t