The prior occlusion of bilateral vertebral arteries during producing global cerebral ischemic damage model may play a protective role as preconditioning

• Published in: Zhongguo ying yong sheng li xue za zhi Vol. 23; no. 1; p. 24
• Main Authors: Geng, Jin-Xia, Zhang, Min, Li, Wen-Bin, Guo, Li-Hua, Li, Qing-Jun, Xian, Xiao-Hui
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2007
• Subjects: Animals; Brain Ischemia - prevention & control; Hippocampus - blood supply; Ischemic Preconditioning - methods; Male; Rats; Rats, Wistar; Vertebral Artery - pathology
• ISSN: 1000-6834

To study the effect of different intervals between occlusions of vertebral arteries and bilateral common carotid arteries on the Pulsinelli 4-vessel occlusion global cerebral ischemic model, and the features of ischemia of the brainstem and hippocampus induced by occulusion of bilateral common carotid arteries under the condition of occlusion of unilateral vertebral artery. Eighty four adult male Wistar rats were divided into 4 groups randomly: control group, bilateral vertebral artery occluding group, global brain ischemic insult group, and unilateral vertebral artery occluding plus bilateral common carotid arteries occluding group. In the global brain ischemic insult group, rats were further divided into 24 h, 48 h, and 72 h interval subgroups according to the interval between the occlusion of the vertebral arteries and bilateral common carotid arteries. The responses including enlarging of pupils and the light reflex during the brain ischemia were observed. The duration of right reflex disappearing, the ge