Megakaryocytic dysplasia and leukemia associated phenotype in elderly patients with acute myeloid leukemia

This study was purposed to investigate the megakaryocytic dysplasia and leukemia-associated phenotypes (LAP) of acute myeloid leukemia (AML) in the elderly. The megakaryocytic dysplasia, lineage infidelity, asynchronous antigen expression, total WBC count, and karyotypes were observed in the 147 non...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 16; no. 5; p. 1107
Main Authors Qin, Ji-Xia, Xu, Juan, Sun, Xue-Jing, Liu, Cong-Yan, Wan, Sui-Gui, Hui, Wu-Han, Zhuang, Guang-Yan, Zhao, Hong
Format Journal Article
LanguageChinese
Published China 01.10.2008
Subjects
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Female
Humans
Immunophenotyping
Leukemia, Myeloid, Acute - immunology
Leukemia, Myeloid, Acute - pathology
Logistic Models
Male
Megakaryocytes - pathology
Middle Aged
Prognosis
Young Adult
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Summary:This study was purposed to investigate the megakaryocytic dysplasia and leukemia-associated phenotypes (LAP) of acute myeloid leukemia (AML) in the elderly. The megakaryocytic dysplasia, lineage infidelity, asynchronous antigen expression, total WBC count, and karyotypes were observed in the 147 none M(3)-AML patients. Logistic regression were used to analyzed the difference between the elderly (age > or = 60) and the control. The results showed that out of the total 147 patients (66 elderly patients, and 81 younger patients) 124 patients accepted induction chemotherapy, in which 70 cases achieved complete remission (elderly 18, younger 52, p = 0.008); megakaryocytic dysplasia was found in 32 patients (21.8%); CD33 and CD19/CD7 (lineage infidelity) was co-expressed in 55 patients (37.4%), CD34 and CD11b (asynchronous antigen expression) was co-expressed in 65 patients (44.2%); white blood cell count > 25 x 10(9)/L was found in 52 patients (35.4%). By the Logistic regression, compared with the control, in the
ISSN:1009-2137