Comparison of pathologic and clinical characteristics of young and old patients with advanced rectal cancer after neoadjuvant radiotherapy

To address the difference of pathologic and clinical characteristics of the young and the middle-aged and elderly patients with advanced rectal cancer after neoadjuvant radiotherapy. A total of 252 patients undergoing radical surgery from January 2000 to January 2005 were included in this study. The...

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Published inChung-hua wai kʿo tsa chih Vol. 48; no. 21; p. 1616
Main Authors Du, Chang-zheng, Zhang, Ji-shui, Li, Ming, Zhao, Jun, Peng, Yi-fan, Yao, Yun-feng, Xue, Wei-cheng, Gu, Jin
Format Journal Article
LanguageChinese
Published China 01.11.2010
Subjects
Adult
Age Factors
Aged
Female
Follow-Up Studies
Humans
Male
Middle Aged
Preoperative Care
Prognosis
Radiotherapy, Adjuvant
Rectal Neoplasms - pathology
Rectal Neoplasms - radiotherapy
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Summary:To address the difference of pathologic and clinical characteristics of the young and the middle-aged and elderly patients with advanced rectal cancer after neoadjuvant radiotherapy. A total of 252 patients undergoing radical surgery from January 2000 to January 2005 were included in this study. The patients were divided into two groups according to the age at diagnosis:young-patient group (< 40 years) and old-patient group (≥ 40 years). The pathologic and clinical materials were collected and the oncologic outcome was compared between the two arms. A total of 252 patients were included in this study, included 54 patients in young-patient group and 198 patients in old-patient group, respectively. There was no significant difference in gender, clinical stage and pretreatment serum carcinoembryonic antigen (CEA) between the two groups. However, the proportion of mucinous and signet-ring cell cancer was significantly higher in young-patient group (20.4% vs. 4.0%, P < 0.05), and furthermore, the proportion of pat
ISSN:0529-5815