Influence of stapedectomy on the hearing of guinea pigs

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 27; no. 8; p. 1206
• Main Authors: Yan, Xing, Xie, Nan-Ping, Shu, Si-Yun, Qian, Yu-Hong
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2007
• Subjects: Animals; Auditory Threshold - physiology; Evoked Potentials, Auditory, Brain Stem - physiology; Female; Guinea Pigs; Hair Cells, Auditory - cytology; Hearing - physiology; Male; Round Window, Ear - cytology; Round Window, Ear - physiology; Round Window, Ear - surgery; Stapes Surgery - adverse effects; Time Factors
• ISSN: 1673-4254

To compare the influences of stapedectomy and small fenestra stapedotomy on the hearing of guinea pigs. Twenty-four (48 ears) guinea pigs were randomized equally into two groups, and the left ears were subjected to stapedectomy and total stapes replacement with a prosthesis, or sham operation (12 ears) to expose the footplate of the stapes and the round window. Each guinea pig was tested by ABR perioperatively. Four guinea pigs were chosen randomly from each group and decapitated for morphological examination by light microscopy and scanning electron microscopy after ABR test. In the sham operation group, the post-operative latencies of each wave, the intervals and the hearing threshold exhibited no significant changes other than prolonged latency of wave I. In stapedectomy group, the hearing threshold increased to 23.75-/+3.77 dBSPL 1 h after operation with significantly prolonged post-operative latencies of all the waves and intervals but for III-IV interval, which was shortened. The latencies of each wave