The significance and the expression of homeobox genes during human burn wound healing

To investigate the expression of several homeobox genes during the wound healing in fetal and adult skin and their roles in fetal scarless wound healing. The expressions of PRX-2, HOXB13, HOX2.2 and HOX2.3 during wound healing in fetal and adult skin were determined with in situ hybridization. (1) P...

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Published inZhonghua shao shang za zhi Vol. 19; no. 2; p. 112
Main Authors Song, Hui-Feng, Chai, Jia-Ke, Chen, Min-Liang, Lin, Zi-Hao, Liu, Ning-Fei, Yuan, Xiang-Bin, Chen, Bao-Jü, Sheng, Zhi-Yong
Format Journal Article
LanguageChinese
Published China 01.04.2003
Subjects
Adolescent
Adult
Animals
Burns - pathology
Child
Female
Fetus
Gene Expression
Genes, Homeobox
Homeodomain Proteins - metabolism
Humans
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Skin - embryology
Wound Healing - genetics
Young Adult
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Summary:To investigate the expression of several homeobox genes during the wound healing in fetal and adult skin and their roles in fetal scarless wound healing. The expressions of PRX-2, HOXB13, HOX2.2 and HOX2.3 during wound healing in fetal and adult skin were determined with in situ hybridization. (1) PRX-2 positive expression could be identified in normal fetal and adult skin, especially in the fetus. But there was difference in location sites of the genes. The positive expression in normal fetal skin was mainly found in the peripheral cells at the hair shafts within dermal papilla layers and was also found in the epithelium. Nevertheless, weak positive expression of PRX-2 was found in the epithelial basal layer cells in normal adult skin but not in dermal tissue. There was strong positive expression of the PRX-2 in the tissue around the wound in fetus but not of that in adults except the epithelial basal layers. (2) Positive expression of HOXB13 could be identified in both normal fetal and adult skins. And the
ISSN:1009-2587