Changes in tight junction of intestinal mucosa in patients with irritable bowel syndrome: a study with tracing electron microscope

To investigate the presence of tight junction (TJ) changes of the intestinal mucosa, and elucidate the possible mechanism for changes in bowel evacuation in patients with irritable bowel syndrome (IBS). In 10 normal control subjects, 10 patients with constipation predominant IBS (C-IBS) and 10 with...

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Bibliographic Details
Published inNan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 27; no. 8; p. 1167
Main Authors Kong, Wu-Ming, Gong, Jun, Dong, Lei, Chen, Ming-Xia
Format Journal Article
LanguageChinese
Published China 01.08.2007
Subjects
Adolescent
Adult
Aged
Case-Control Studies
Female
Humans
Intestinal Mucosa - cytology
Intestinal Mucosa - pathology
Intestinal Mucosa - ultrastructure
Irritable Bowel Syndrome - pathology
Male
Microscopy, Electron
Middle Aged
Tight Junctions - pathology
Tight Junctions - ultrastructure
Young Adult
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ISSN1673-4254

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Summary:To investigate the presence of tight junction (TJ) changes of the intestinal mucosa, and elucidate the possible mechanism for changes in bowel evacuation in patients with irritable bowel syndrome (IBS). In 10 normal control subjects, 10 patients with constipation predominant IBS (C-IBS) and 10 with diarrhea predominant IBS (D-IBS), biopsies were taken from the terminal ileum and ascending colon. Lanthanum nitrate tracing electron microscope and cytochemical technique were employed to observe TJ changes in the intestinal mucosa. Like the control subjects, C-IBS patients had normal TJ structure in the intestinal mucosa, whereas D-IBS patients exhibited some abnormalities in TJ structure either in their terminal ileum (7 in 10) or ascending colon (8 in 10), revealed by TJ gap widening with lanthanum nitrate extravasation into the surrounding tissue. Such changes were also observed in 3 of the 4 patients with a history of acute infectious diarrhea. The changes in the intestinal mucosal TJ structure and function m
ISSN:1673-4254