A molecular epidemiological study on human plague fulminant epidemic in Qinghai, 2004

To study the epidemiology of genotyping Yersinia pestis isolated in the fulminant epidemics of human plague in Qinghai province in 2004. Primer pairs targeting the twenty-three different identified regions (DFRs) were designed to detect the presence or deletion of each DFR in 13 strains of Yersinia...

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Published inZhōnghuá liúxíngbìng zázhì Vol. 27; no. 4; p. 316
Main Authors Qi, Zhi-zhen, Dai, Er-hei, Zhou, Dong-sheng, Yang, Yong-hai, Yu, Shou-hong, Dai, Rui-xia, Zhao, Hai-hong, Li, Min, Yang, Rui-fu
Format Journal Article
LanguageChinese
Published China 01.04.2006
Subjects
China - epidemiology
Disease Outbreaks
Genotype
Humans
Molecular Epidemiology
Plague - epidemiology
Yersinia pestis - genetics
Yersinia pestis - isolation & purification
China
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Summary:To study the epidemiology of genotyping Yersinia pestis isolated in the fulminant epidemics of human plague in Qinghai province in 2004. Primer pairs targeting the twenty-three different identified regions (DFRs) were designed to detect the presence or deletion of each DFR in 13 strains of Yersinia pestis isolated from the fulminant epidemic of human plague in Qinghai province in 2004. There were 4 genomovars, i.e. Genomovar 8, 10, 15 and 16 in the 13 strains of Yersinia pestis identified. The genomovar of all the strains of Yersinia pestis isolated from Nangqian county was Genomovar 10. Among the two strains of Yersinia pestis isolated from Wulan county, the genomovar of one strain was Genomovar 8 and the other was Genomovar 10. The genomovars of all the strains of Yersinia pestis isolated from Qilian, Qumalai and Chengduo county belonged to Genomovar 16. It was demonstrated that the genotyping of Yersinia pestis appeared to be a powerful tool for investigating human plague epidemics.
ISSN:0254-6450