Effect of external retinoic acid on Tbx1 gene during zebrafish embryogenesis

• Published in: Zhonghua er ke za zhi Vol. 45; no. 4; p. 267
• Main Authors: Zhang, Li-Feng, Gui, Yong-Hao, Zhong, Tao, Wang, Yue-Xiang, Qian, Lin-Xi, Dong, Yong-Xin, Jiang, Qiu, Sun, Shu-Na, Song, Hou-Yan
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2007
• Subjects: Animals; Branchial Region - drug effects; Branchial Region - embryology; Embryo, Nonmammalian - drug effects; Embryonic Development - drug effects; Gene Expression Regulation, Developmental; Heart - drug effects; Heart - embryology; T-Box Domain Proteins - genetics; T-Box Domain Proteins - metabolism; Tretinoin - pharmacology; Zebrafish - embryology; Zebrafish - genetics; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism

DiGeorge/del22q11 syndrome is one of the most common genetic causes of outflow tract and aortic arch defects in human. DiGeorge/del22q11 is thought to involve an embryonic defect restricted to the pharyngeal arches and the corresponding pharyngeal pouches. Previous studies have evidenced that retino...