Effect of external retinoic acid on Tbx1 gene during zebrafish embryogenesis

• Published in: Zhonghua er ke za zhi Vol. 45; no. 4; p. 267
• Main Authors: Zhang, Li-Feng, Gui, Yong-Hao, Zhong, Tao, Wang, Yue-Xiang, Qian, Lin-Xi, Dong, Yong-Xin, Jiang, Qiu, Sun, Shu-Na, Song, Hou-Yan
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2007
• Subjects: Animals; Branchial Region - drug effects; Branchial Region - embryology; Embryo, Nonmammalian - drug effects; Embryonic Development - drug effects; Gene Expression Regulation, Developmental; Heart - drug effects; Heart - embryology; T-Box Domain Proteins - genetics; T-Box Domain Proteins - metabolism; Tretinoin - pharmacology; Zebrafish - embryology; Zebrafish - genetics; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism
• ISSN: 0578-1310

DiGeorge/del22q11 syndrome is one of the most common genetic causes of outflow tract and aortic arch defects in human. DiGeorge/del22q11 is thought to involve an embryonic defect restricted to the pharyngeal arches and the corresponding pharyngeal pouches. Previous studies have evidenced that retinoic acid (RA) signaling is definitely indispensable for the development of the pharyngeal arches. Tbx1, one of the T-box containing genes, is proved to be the most attractive candidate gene for DiGeorge/del22q11 syndrome. However, the interaction between RA and Tbx1 has not been fully investigated. Exploring the interaction will contribute to discover the molecular pathways disrupted in DiGeorge/del22q11 syndrome, and will also be essential for understanding genetic basis for congenital heart disease. It now seems possible that genes and molecular pathways disrupted in DiGeorge syndrome will also account for some isolated cases of congenital heart disease. Accordingly, the present study aimed to extensively study th