Designer Natriuretic Peptides
Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that...
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| Published in | Journal of investigative medicine Vol. 57; no. 1; pp. 18 - 21 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
01.01.2009
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| Online Access | Get full text |
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| Abstract | Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that were designed in our laboratory are reviewed, and future directions for research and development of designer NPs are discussed. |
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| AbstractList | Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that were designed in our laboratory are reviewed, and future directions for research and development of designer NPs are discussed. |
| Author | Lee, Candace Y. W. Lieu, Hsiao Burnett, John C. |
| AuthorAffiliation | Cardiorenal Research Laboratory, Division of Cardiovascular Disease, Departments of Internal Medicine and Physiology, Mayo Clinic College of Medicine, Rochester, MN Nile Therapeutics, San Francisco, CA |
| AuthorAffiliation_xml | – name: Cardiorenal Research Laboratory, Division of Cardiovascular Disease, Departments of Internal Medicine and Physiology, Mayo Clinic College of Medicine, Rochester, MN – name: Nile Therapeutics, San Francisco, CA |
| Author_xml | – sequence: 1 givenname: Candace Y. W. surname: Lee fullname: Lee, Candace Y. W. organization: Cardiorenal Research Laboratory, Division of Cardiovascular Disease, Departments of Internal Medicine and Physiology, Mayo Clinic College of Medicine, Rochester, MN Nile Therapeutics, San Francisco, CA – sequence: 2 givenname: Hsiao surname: Lieu fullname: Lieu, Hsiao organization: Cardiorenal Research Laboratory, Division of Cardiovascular Disease, Departments of Internal Medicine and Physiology, Mayo Clinic College of Medicine, Rochester, MN Nile Therapeutics, San Francisco, CA – sequence: 3 givenname: John C. surname: Burnett fullname: Burnett, John C. organization: Cardiorenal Research Laboratory, Division of Cardiovascular Disease, Departments of Internal Medicine and Physiology, Mayo Clinic College of Medicine, Rochester, MN Nile Therapeutics, San Francisco, CA |
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| Copyright | Copyright © 2009 by The American Federation for Medical Research 2009 |
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| DOI | 10.231/JIM.0b013e3181946fb2 |
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