Expression and clinical significance of IL-17 and IL-21 in patients with acute leukemia

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 18; no. 5; p. 1143
• Main Authors: Su, Mei-Fang, Wang, Chang-Feng, Zhao, Yong-Mei, Wu, Ji-Xiong, Zhang, Yao
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2010
• Subjects: Adolescent; Adult; Case-Control Studies; CD4-Positive T-Lymphocytes; Female; Humans; Interleukin-17 - metabolism; Interleukins - metabolism; Leukemia, Myeloid, Acute - metabolism; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism; Th17 Cells - secretion; Young Adult
• ISSN: 1009-2137

This study was aimed to investigate the effects of peripheral blood Th17 cells, IL-17 and IL-21 in the occurrence and development of acute leukemia. 60 patients with acute leukemia (19 patients with ALL, 41 patients with AML) were divided into non-remission group (group A, n=24), remission group (group B, n=36); 25 healthy volunteers were used as control group (group C). In addition to this, these 60 patients were divided into infection group (n=32) and non-infection group (n=28) on the basis of infection status. The concentration of IL-17 and IL-21 in the peripheral blood mononuclear cell culture supernatant after stimulation with anti-CD3 and anti-CD28 mAb were determined with ELISA. The expression of CD4+ IL-17+ cells was determined by flow cytometry. The results showed that (1) the concentrations of IL-17 and IL-21, and proportion of Th17 cells in group A and group B were much lower than those in group C (p<0.05); (2) the expression levels of IL-17 and IL-21, and the proportion of Th17 cells in group A we