Cost-effectiveness of routine (18)F-FDG PET/CT in high-risk patients with gram-positive bacteremia

• Published in: The Journal of nuclear medicine (1978) Vol. 52; no. 11; pp. 1673 - 1678
• Main Authors: Vos, Fidel J, Bleeker-Rovers, Chantal P, Kullberg, Bart Jan, Adang, Eddy M M, Oyen, Wim J G
• Format: Journal Article
• Language: English
• Published: United States 01.11.2011
• Subjects: Bacteremia - diagnostic imaging; Bacteremia - economics; Bacteremia - therapy; Cost-Benefit Analysis; Delivery of Health Care - economics; Early Diagnosis; Fluorodeoxyglucose F18 - economics; Humans; Multimodal Imaging - economics; Positron-Emission Tomography; Recurrence; Risk; Tomography, X-Ray Computed
• ISSN: 1535-5667
• DOI: 10.2967/jnumed.111.089714

Gram-positive bacteremia has a high morbidity and mortality rate of approximately 30%. Delayed diagnosis of clinically silent metastatic infectious foci is an important indicator for a complicated outcome. (18)F-FDG PET/CT allows detection of focal infection, resulting in lower relapse rates and mortality. Here, we present a cost-effectiveness analysis associated with introduction of (18)F-FDG PET/CT for patients with gram-positive bacteremia. A cost-effectiveness analysis in a prospective (18)F-FDG PET/CT group (n = 115) and matched control group (n = 230) was performed alongside a clinical study, the results of which were previously published. Mortality at 6 mo was considered the final effect outcome and was used in the denominator of the incremental cost-effectiveness ratio. Mortality in the (18)F-FDG PET/CT group was 19%, compared with 32% in the control group (P < 0.01). Incremental costs of (18)F-FDG PET/CT were $9,454 (95% confidence interval [CI], $3,963-$14,947), mainly because of admission (mean, $6,631; 95% CI, $1,449-$11,814). Additional costs were related to echocardiography (P < 0.01), not to (18)F-FDG PET/CT (P = 0.8). The mean incremental costs of the (18)F-FDG PET/CT strategy estimated by stratification for endocarditis were $5,277 per patient (95% CI, $429-$10,123; P = 0.03). The point estimate of the incremental cost-effectiveness ratio is $72,487 per prevented death (95% CI, $11,388-$323,379). Introduction of a diagnostic regimen including routine (18)F-FDG PET/CT decreases morbidity and mortality. The cost increase is due to in-hospital treatment of metastatic infectious foci. Costs per prevented death, $72,487, are within the range that is considered to be efficient by Dutch guidelines. Patients with high-risk gram-positive bacteremia therefore should have easy access to (18)F-FDG PET/CT to enable early detection of metastatic infectious disease.