Cholestasis and biliary dilatation associated with chronic ketamine abuse: a case series

Ketamine is a dissociative anaesthetic agent that is still widely used in veterinary and human medicine. It is increasingly being used as a recreational hallucinogenic drug. Chronic ketamine abuse is known to account for lower urinary tract symptoms and urinary bladder dysfunction. There is now emer...

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Bibliographic Details
Published inSingapore medical journal Vol. 52; no. 3; pp. e52 - e55
Main Authors Lo, R S C, Krishnamoorthy, R, Freeman, J G, Austin, A S
Format Journal Article
LanguageEnglish
Published Singapore 01.03.2011
Subjects
Adult
Anesthetics, Dissociative - pharmacology
Biliary Tract - abnormalities
Cholangiopancreatography, Endoscopic Retrograde - methods
Cholestasis - drug therapy
Cholestasis - etiology
Dilatation, Pathologic - drug therapy
Dyskinesias - etiology
Humans
Jaundice, Obstructive - therapy
Ketamine - pharmacology
Male
Radiography, Abdominal - methods
Substance-Related Disorders
Urinary Tract - drug effects
Urologic Diseases - chemically induced
Urologic Diseases - pathology
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Summary:Ketamine is a dissociative anaesthetic agent that is still widely used in veterinary and human medicine. It is increasingly being used as a recreational hallucinogenic drug. Chronic ketamine abuse is known to account for lower urinary tract symptoms and urinary bladder dysfunction. There is now emerging evidence that ketamine misuse is also associated with abnormal liver function tests and biliary tract abnormality. We report three cases of chronic ketamine misuse in three young men who all presented with obstructive jaundice and biliary tract abnormality. We also describe the clinical features, radiological findings and potential underlying mechanisms for this new entity.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ISSN:0037-5675