Expression of aquaporin-1 and Bcl-2 mRNA in eosinophils of the nasal polyps and its significance

To study the significance of aquaporin-1 (AQP-1) expression in the eosinophils of nasal polyps. The expression and location of AQP-1 mRNA and apoptosis associated gene Bcl-2 mRNA in nasal polyps were explored. Sixteen nasal polyp samples were collected from 11 women and 5 men aged 20-65 years during...

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Published inZhonghua er bi yan hou ke za zhi Vol. 39; no. 8; p. 476
Main Authors Guan, Gui-mei, Dong, Zhen, Lü, Mei
Format Journal Article
LanguageChinese
Published China 01.08.2004
Subjects
Adolescent
Adult
Aged
Aquaporin 1 - metabolism
Case-Control Studies
Eosinophils - metabolism
Female
Humans
Male
Middle Aged
Nasal Polyps - metabolism
Proto-Oncogene Proteins c-bcl-2 - metabolism
RNA, Messenger - genetics
Young Adult
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Summary:To study the significance of aquaporin-1 (AQP-1) expression in the eosinophils of nasal polyps. The expression and location of AQP-1 mRNA and apoptosis associated gene Bcl-2 mRNA in nasal polyps were explored. Sixteen nasal polyp samples were collected from 11 women and 5 men aged 20-65 years during routine endonasal surgery. Nasal mucosa specimens from the inferior turbinates of 10 patients with allergic rhinitis (7 women and 3 men, aged 16-58 years), collected during septoplasty, were used as controls. The expression of AQP-1 mRNA and Bcl-2 mRNA was detected in serial adjacent sections by in situ hybridization and eosinophils were examined by stain MGG. AQP-1 mRNA expression was found in all 16 nasal polyps and in 4 of 10 inferior turbinate tissues, the mean expression rates were (93.16 +/- 13.25)% and (19.54 +/- 4.98)%, respectively. All 16 nasal polyps and 10 control nasal tissues expressed Bcl-2 mRNA, by the average rates of (84.74 +/- 12.10)% and (16.45 +/- 3.12)%, respectively. The expression of AQP-1
ISSN:0412-3948