Expression of carcinoembryonic antigen receptor in digestive organs

To explore the significance of the expression of carcinoembryonic antigen receptors (CEAR) in digestive organs. Specimens were procured from 20 male BALB/c mice including esophagus, small intestine, stomach, colon, pancreas, and liver. Kupffer cells were obtained by density gradient centrifugation f...

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Bibliographic Details
Published inZhonghua wei chang wai ke za zhi Vol. 13; no. 8; p. 608
Main Authors Zhao, Hui-min, Zhang, Sen, Gao, Feng
Format Journal Article
LanguageChinese
Published China 01.08.2010
Subjects
Animals
Carcinoembryonic Antigen - metabolism
Colon - metabolism
Esophagus - metabolism
Intestine, Small - metabolism
Kupffer Cells - metabolism
Liver - metabolism
Male
Mice
Mice, Inbred BALB C
Pancreas - metabolism
Receptors, Cell Surface - metabolism
Stomach - metabolism
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Summary:To explore the significance of the expression of carcinoembryonic antigen receptors (CEAR) in digestive organs. Specimens were procured from 20 male BALB/c mice including esophagus, small intestine, stomach, colon, pancreas, and liver. Kupffer cells were obtained by density gradient centrifugation following enzymatic digestion of the fresh liver specimen. Immunohistochemistry and immunocytochemistry methods were used to detect CEAR in those organs or Kupffer cells. CEAR was found both in cytoplasm and nuclei of the digestive tract mucosal epithelial cells and pancreas islet cells, but only in the cytoplasm of liver cells, Kupffer cells, and smooth muscle cells of the whole digestive tract. The mean ranks of CEAR expression were 174.33 in the mucosal epithelial cells of colon, 160.70 in epithelial cells of small intestine, 139.18 in Kupffer cells, 137.43 in pancreas islet cells, 131.70 in liver cells, 124.23 in gastric epithelial cells, 77.15 in esophageal epithelial cells and 57.80-71.00 in smooth muscle cell
ISSN:1671-0274