A sharp rise in portal vein pressure, not arterial constriction, initiates bile salt-induced pancreatic microcirculatory disturbance

It was reported that pancreatic arteries constricted during the early phase of bile salt-induced acute pancreatitis (AP), leading to pancreatic microcirculatory disturbance. We conducted this experiment to verify whether the above-mentioned finding was true. AP was induced with intraductal injection...

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Published inSheng wu yi xue gong cheng xue za zhi Vol. 24; no. 6; p. 1280
Main Authors Chen, Youdai, Chen, Huaiqing, Tang, Yunman, Tu, Qiufen, Ge, Dongxia, Yu, Chang, Jiang, Congxun, Liao, Shiping, Wang, Ron
Format Journal Article
LanguageChinese
Published China 01.12.2007
Subjects
Animals
Bile Acids and Salts - adverse effects
Hypertension, Portal - complications
Male
Microcirculation - drug effects
Microcirculation - physiology
Pancreas - blood supply
Pancreatitis - etiology
Pancreatitis - physiopathology
Portal Pressure
Portal Vein - physiopathology
Rats
Rats, Sprague-Dawley
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Summary:It was reported that pancreatic arteries constricted during the early phase of bile salt-induced acute pancreatitis (AP), leading to pancreatic microcirculatory disturbance. We conducted this experiment to verify whether the above-mentioned finding was true. AP was induced with intraductal injection of taurodeoxyholate. Small pancreatic artery pressure in dogs was recorded. Functional capillaries were counted and calibrated by multiplying wet weight of pancreas. Pancreatic perfusion was measured with Laser Doppler flowmeter. Pancreatic arterioles of rats dilated during the initial 20 min of AP, and pancreatic arterial pressure declined during the early phase of AP in dogs (from 104.5 +/- 4.8 mmHg to 54.6 +/- 5.6 mmHg). The hematocrit of blood from inferior vena cava was significantly lower than that of portal vein at 5 min after pancreatitis induction. The "true" pancreatic functional capillary density increased. The early pancreatic microcirculatory disturbance coincided with a marked increase of portal vein
ISSN:1001-5515