Regulating effects of delayed rectifier potassium channel on the tone of human passively sensitized bronchial smooth muscle

To investigate the role of delayed rectifier K+ channel (Kv), Ca2+ -activated K+ channel (K(Ca)) and ATP-sensitive K+ channel (K(ATP)) in the regulation of the resting and contracting tone of human control and passively sensitized bronchial smooth muscle (BSM). The regulating effects of the three K+...

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Published inZhongguo ying yong sheng li xue za zhi Vol. 22; no. 3; p. 348
Main Authors Zhao, Li-min, Xu, Yong-jian, Zhang, Zhen-xiang, Cheng, Dong-jun, Ni, Wang
Format Journal Article
LanguageChinese
Published China 01.08.2006
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Summary:To investigate the role of delayed rectifier K+ channel (Kv), Ca2+ -activated K+ channel (K(Ca)) and ATP-sensitive K+ channel (K(ATP)) in the regulation of the resting and contracting tone of human control and passively sensitized bronchial smooth muscle (BSM). The regulating effects of the three K+ channels on the tone of human BSM (HBSM) were observed by measuring the isometric tone of bronchial rings in vitro. (1) The contraction of passively sensitized bronchial ring was significantly increased by histamine. (2) Kv blocker 4-aminopyridine (4-AP) caused concentration dependent contraction in resting bronchial rings of two groups, and the contraction sensitivity of the sensitized group rings was significantly stronger than that of control, that is, the negative logarithm of the drug concentration causing 50% of maximal effect (pD2) of the sensitized group rings were significantly larger than that of control rings, but there was no difference in the maximal effect (Emax) of two groups; Kca blocker tetraethyl
ISSN:1000-6834