Expression of lipopolysaccharide receptors CD14 and TLR4 in a model of rat molar apical periodontitis

To characterize the expression of lipopolysaccharide (LPS) receptors-CD14 and TLR4 in rat peri-radicular tissue and to investigate the signal transduction pathway of LPS and its receptors in periapical periodontitis. After establishment of a model of rat molar LPS-induced apical periodontitis, CD14...

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Bibliographic Details
Published inZhonghua kouqiang yixue zazhi Vol. 42; no. 3; p. 148
Main Authors Zhang, Chen, Hou, Ben-xiang
Format Journal Article
LanguageChinese
Published China 01.03.2007
Subjects
Animals
Disease Models, Animal
Lipopolysaccharide Receptors - metabolism
Lipopolysaccharides - toxicity
Periapical Periodontitis - chemically induced
Periapical Periodontitis - metabolism
Periapical Periodontitis - pathology
Rats
Rats, Sprague-Dawley
Signal Transduction
Toll-Like Receptor 4 - metabolism
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Summary:To characterize the expression of lipopolysaccharide (LPS) receptors-CD14 and TLR4 in rat peri-radicular tissue and to investigate the signal transduction pathway of LPS and its receptors in periapical periodontitis. After establishment of a model of rat molar LPS-induced apical periodontitis, CD14 and TLR4 expression in healthy and inflammatory periapical tissue were determined by immunohistochemistry. CD14 and TLR4 were not detected in healthy periapical tissue but strongly positive in inflammatory periapical tissue. Positive cells were mostly monocytes/macrophages. CD14 and TLR4 may play an important role in the pathogenesis of periapical periodontitis, probably via immune cells such as monocytes/macrophages and neutrophils.
ISSN:1002-0098