Study on the association between polymorphism of TAP1 637 A/G alleles polymorphism and metabolic syndrome

• Published in: Zhōnghuá liúxíngbìng zázhì Vol. 28; no. 3; p. 286
• Main Authors: Hu, Xiao-shu, Guo, Zhi-rong, Shen, Chong, Wu, Ming, Yu, Rong-bin, Yao, Cai-liang
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2007
• Subjects: Adult; ATP-Binding Cassette Sub-Family B Member 2; ATP-Binding Cassette Transporters - genetics; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Male; Metabolic Syndrome - genetics; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length
• ISSN: 0254-6450

To explore the effect of the transporter 1 associated with antigen processing (TAP1) gene 637 A/G polymorphism on the risk of metabolic syndrome(MS). A case-control study was conducted on 138 based-community patients (68 males and 70 females, 61.31 +/- 11.00 years old) diagnosed as MS with 162 healthy subjects (74 males and 88 females, 48.73 +/- 11.66 years old) came from the same origin as cases. The allele polymorphisms TAP1 637 A/G was examined by the specificity restriction fragment length polymorphism-polymerase chain reaction(RFLP-PCR) method with genomic DNA. The effect of TAP1 637 A/G polymorphisms on MS were analyzed by multivariable unconditional logistic regression models. The TAPI 637 A/G allele genotypes frequencies (83.3%, 16.7%) contribution in control group were consistent with the distribution predicted by Hardy-Weinberg equilibrium (chi2 = 1.46, P > 0.05). TAP1 637 G allele genotypes frequencies (26.1%) of cases were significantly higher than controls (16.7%) with P = 0.005. There were signi