Analysis of maternal and neonatal factors associated with hematopoietic reconstruction potential in umbilical cord blood units

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 18; no. 6; p. 1535
• Main Authors: Wu, Jie-Ying, Liao, Can, Chen, Jin-Song, Xu, Zun-Peng, Gu, Shao-Ling, Wu, Shao-Qing, Lu, Yan, Xie, Gui-E
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2010
• Subjects: Adult; Birth Weight; Blood Banking - methods; Cord Blood Stem Cell Transplantation - methods; Delivery, Obstetric; Donor Selection; Female; Fetal Blood - cytology; Fetal Blood - immunology; Gestational Age; Hematopoietic Stem Cells; Humans; Infant, Newborn; Male; Maternal Age; Pregnancy; Young Adult
• ISSN: 1009-2137

Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cells for transplantation with success being associated with the total nucleated cell (TNC) count, CD34(+) cells and colony-forming unit-granulocyte-macrophage (CFU-GM) content infused. This study was purposed to clarify the impact of maternal and neonatal factors on hematopoietic potential of UCB product. UCB samples were screened, processed, tested and cryopreserved according to the Standard Operation Procedure (SOP) of Guangzhou cord blood bank (GZCBB). Relationship of hematopoietic cell parameters with maternal and neonatal characteristics for 4615 UCB units was analyzed retrospectively. The results showed that both collected volume (Mean ± SD: 95.23 ± 22.42 ml; Median: 91.85 ml) and initial TNC [Mean ± SD: (1.34 ± 0.49) × 10(9); Median: 1.25 × 10(9)] correlated well with postprocessed TNC [Mean ± SD: (1.21 ± 0.42) × 10(9); Median: 1.14 × 10(9); p < 0.001], CD34(+)count [Mean ± SD: (5.14 ± 4.55) × 10(6); Median: 4.08 × 10(6); p < 0.