Effect of losartan, lisinopril and their combination on hemodynamics and morphofunctional parameters of the heart in patients with chronic cardiac failure

The aim of the study was to evaluate effects of losartan receptor I antagonist (AT) and/or angiotensin converting enzyme inhibitor (iACE) on clinical manifestations of the disease, hemodynamic characteristics, morphofunctional heart parameters in patients with chronic cardiac insufficiency (CHI) com...

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Bibliographic Details
Published inKlinicheskaia meditsina Vol. 89; no. 1; p. 40
Main Authors Tofan, E F, Butorov, I V, Gonchar, V I, Nekula, G I
Format Journal Article
LanguageRussian
Published Russia (Federation) 2011
Subjects
Aged
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Cardiotonic Agents - therapeutic use
Drug Therapy, Combination
Echocardiography
Exercise Test
Female
Follow-Up Studies
Heart Failure - diagnosis
Heart Failure - drug therapy
Heart Failure - physiopathology
Hemodynamics - drug effects
Humans
Lisinopril - therapeutic use
Losartan - therapeutic use
Male
Middle Aged
Treatment Outcome
Ventricular Function - drug effects
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Summary:The aim of the study was to evaluate effects of losartan receptor I antagonist (AT) and/or angiotensin converting enzyme inhibitor (iACE) on clinical manifestations of the disease, hemodynamic characteristics, morphofunctional heart parameters in patients with chronic cardiac insufficiency (CHI) complicating coronary heart disease (CHD). A total of 60 patients aged 48-72 (mean 62 +/- 8.4) years with persistent symptoms of functional class II-IV CHI and left ventricular (LV) fraction = < 45% complicating CHD. They were divided into 3 groups of 20 patients each. Patients in group 1 were given losartan (50 mg daily), in group 2 lisinopril (10 mg daily), in group 3 combination of the two drugs for 24 weeks. Combined treatment produced more significant improvement of CHI symptoms than monotherapy with either drug. In all cases, the size of heart left chambers decreased while contractility of left ventricular myocardium increased but these effects were more pronounced after combined therapy.
ISSN:0023-2149