Prognostic value of microvessel density and angiogenesis-related molecules in epithelial ovarian cancer

• Published in: Zhōnghuá zhŏngliú zázhì Vol. 30; no. 4; p. 274
• Main Authors: Tan, Xian-Jie, Lang, Jing-He, Lou, Wei-Zhen, Shen, Keng, Xu, Xiu-Ying
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2008
• Subjects: Adenocarcinoma, Clear Cell - blood supply; Adenocarcinoma, Clear Cell - metabolism; Adenocarcinoma, Clear Cell - pathology; Adult; Aged; Aged, 80 and over; Cystadenocarcinoma, Serous - blood supply; Cystadenocarcinoma, Serous - metabolism; Cystadenocarcinoma, Serous - pathology; Female; Humans; Lymphatic Metastasis; Microvessels - pathology; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Ovarian Neoplasms - blood supply; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Retrospective Studies; Survival Rate; Thrombospondin 1 - metabolism; Tumor Suppressor Protein p53 - metabolism; Vascular Endothelial Growth Factor A - metabolism
• ISSN: 0253-3766

To evaluate the correlations of microvessel density (MVD), vascular endothelial growth factor (VEGF), thrombospodin1 (TSP1) and p53 protein with prognosis in epithelial ovarian cancer. Samples from 57 patients with primary epithelial ovarian cancer were examined by immunohistochemical staining using anti-VEGF, anti-TSP1, anti-p53 and anti-CD34 antibodies. The correlation of MVD, expression of VEGF, TSP1 and p53 protein with postoperative recurrence and overall survival were analyzed retrospectively. VEGF, TSP1 and p53 protein was positively detected in 40 (70.2%), 27 (47.4%) and 35 (61.4%) of those patients, respectively. The mean MVD in this series was 30.3 +/- 8.5. High MVD, positive VEGF expression and negative TSP1 expression were positively correlated with postoperative recurrence. Univariate analysis showed that patients with high MVD, positive expression of VEGF and p53 had shorter median overall survival time than those with lower MVD, negative expression of VEGF and p53 (P = 0.0187, P = 0.010 and P =