A diffusion tensor magnetic resonance imaging for studying white matter changes in patients with mild cognitive impairment.

To measure the microstructural differences in the brains of participants with amnestic mild cognitive impairment (aMCI) and compare with a control group using a magnetic resonance diffusion tensor imaging (DTI) technique with fully automated image analysis tools. A standardized clinical and neuropsy...

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Bibliographic Details
Published inChung-hua nei kʿo tsa chih Vol. 49; no. 2; p. 107
Main Authors Guan, Jin-Qun, Wang, Lu-Ning, Zhang, Xi, Jiang, Tian-Zi, An, Ning-Yu, Wang, Qi-Feng, Zhang, Jun
Format Journal Article
LanguageChinese
Published China 01.02.2010
Subjects
Cognitive Dysfunction
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Humans
Magnetic Resonance Imaging
White Matter
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Summary:To measure the microstructural differences in the brains of participants with amnestic mild cognitive impairment (aMCI) and compare with a control group using a magnetic resonance diffusion tensor imaging (DTI) technique with fully automated image analysis tools. A standardized clinical and neuropsychological evaluation was conducted on each subject. 31 participants (15 participants with aMCI, 16 healthy elderly adults) underwent magnetic resonance imaging (MRI)-based DTI. To control the effects of anatomical variation, the diffusion images of all participants were registered to standard anatomical space. Voxel-by-voxel comparisons showed significant regional reductions in white matter regions of fractional anisotropy (FA) in the participants with aMCI as compared with the controls. Significantly decreased FA value measurements (P < 0.001) were observed in the right frontal white matter in participants with aMCI. Moreover, there was a statistically significant difference between the patients with aMCI and con
ISSN:0578-1426