Expression of hepatocyte growth factor and its receptor in gastric cancer

To investigate the role of expression of hepatocyte growth factor (HGF) and its receptor (c-Met) in gastric cancer. The expression of HGF and c-Met was detected with SABC immunohistochemistry in 44 specimens of gastric cancer, 20 chronic superficial gastritis, 10 chronic atrophic gastritis and 16 ga...

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Published inNan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 27; no. 11; p. 1771
Main Authors Chen, Jun-zhong, Zhao, Yong, Xu, Jia-feng, Liu, Qing, Liu, Sheng-huo, Zhang, Hong-de
Format Journal Article
LanguageChinese
Published China 01.11.2007
Subjects
Adult
Aged
Female
Hepatocyte Growth Factor - metabolism
Humans
Male
Middle Aged
Proto-Oncogene Proteins c-met - metabolism
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Young Adult
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Summary:To investigate the role of expression of hepatocyte growth factor (HGF) and its receptor (c-Met) in gastric cancer. The expression of HGF and c-Met was detected with SABC immunohistochemistry in 44 specimens of gastric cancer, 20 chronic superficial gastritis, 10 chronic atrophic gastritis and 16 gastric ulcer tissues. No positive expression of HGF/c-Met was found in the chronic superficial gastritis specimens. The positivity rates of HGF in the gastric cancer was 72.7% (32/44), significantly higher than that in chronic atrophic gastritis [20% (2/10), P<0.005] and gastric ulcer [37.5% (6/16). P<0.025]. The positivity rates of c-Met in gastric cancer [77.3% (34/44)] was also significantly higher than that in chronic atrophic gastritis [40% (4/10), P<0.05] and gastric ulcer [37.5% (6/16), P<0.025]. Co-expression of HGF and c-Met in gastric cancer may promote the progression of the malignancy, and also opens a new pathway for the therapy of gastric cancer.
ISSN:1673-4254