High-sensitivity C-reactive protein and changes over time in forced expiratory volume in 1 second in adult-onset asthma

To study the possibility that changes in high-sensitivity C-reactive protein (hs-CRP) may be a predictor of forced expiratory volume in 1 second (FEV1) decline over time in adult asthmatic subjects. Subjects with adult-onset asthma with no smoking history underwent complete medical evaluation at Yok...

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Published inNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society Vol. 48; no. 10; p. 719
Main Authors Mizumori, Yasuyuki, Katayama, Satoru, Igishi, Tadashi, Mochiduki, Yoshiro, Nakahara, Yasuharu, Kawamura, Tetsuji, Maniwa, Koji, Makino, Haruhiko, Yamamura, Miki, Terashita, Satoshi
Format Journal Article
LanguageJapanese
Published Japan 01.10.2010
Subjects
Adult
Asthma - blood
Asthma - physiopathology
C-Reactive Protein - analysis
Female
Forced Expiratory Volume
Humans
Male
Smoking - adverse effects
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Summary:To study the possibility that changes in high-sensitivity C-reactive protein (hs-CRP) may be a predictor of forced expiratory volume in 1 second (FEV1) decline over time in adult asthmatic subjects. Subjects with adult-onset asthma with no smoking history underwent complete medical evaluation at Yoka Public Hospital in both 2005 and in 2008 (n = 26). We analyzed the correlation between hs-CRP levels and FEV1 changes over time, in relation to whether or not they received inhaled corticosteroid (ICS) therapy. We also measured the cardio-ankle vascular index (CAVI), intima-media-thickness (IMT), and fraction of exhaled nitric oxide (FeNO) of hospital staff members who acted as non ICS asthmatic subjects (n = 11), and also performed multiple regression analysis. In the non-ICS asthmatic subjects group (n = 19), there was a significant correlation between log (hs-CRP) levels and FEV1 changes (R = -0.734, P < 0.001). After controlling for age, body mass index, CAVI, IMT, and FeNO, hs-CRP was found to be an independent risk factor. Hs-CRP levels are a predictor of FEV1 decline over time in adult-onset asthmatic patients with no smoking history, who are not receiving ICS therapy.
ISSN:1343-3490