Clinical features and survival analysis of patients with CD20 positive adult B-lineage acute lymphoblastic leukemia

The aim of this study was to explore the clinical features and survival of adult patients with CD20 positive B-lineage acute lymphoblastic leukemia (B-ALL). The clinical manifestations, examination results, therapeutic effect and survival rate of 119 adult B-ALL patients diagnosed and treated in our...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 18; no. 2; p. 477
Main Authors Ma, Jie, Sun, Hui, Chen, Sheng-Mei, Liu, Lin-Xiang, Chen, Shao-Qian, Liu, Yan-Fang, Xie, Xin-Sheng, Meng, Xiao-Li, Deng, Mei, Zhang, Qiu-Tang, Li, Tao
Format Journal Article
LanguageChinese
Published China 01.04.2010
Subjects
Adolescent
Adult
Antigens, CD20 - metabolism
Female
Humans
Leukemia, B-Cell - mortality
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality
Prognosis
Retrospective Studies
Survival Analysis
Survival Rate
Young Adult
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Summary:The aim of this study was to explore the clinical features and survival of adult patients with CD20 positive B-lineage acute lymphoblastic leukemia (B-ALL). The clinical manifestations, examination results, therapeutic effect and survival rate of 119 adult B-ALL patients diagnosed and treated in our hospital from May 2004 to January 2008 were analyzed retrospectively. The results showed that among 119 cases, CD20 positive B-ALL accounted for 40 cases (33.61%), CD20 negative B-ALL patents accounted for 79 cases (66.39), the percentage of male patients in CD20 positive and negative groups were 72.50% and 50.63%, the leukocyte counts at diagnosis in these two groups were (27.35+/-30.29)x10(9)/L and (0.11+/-81.72)x10(9)/L, respectively, there were significant differences (p<0.05), whereas the distribution of age, infiltration of liver, spleen, lymph nodes and central nervous system, the hemoglobin and platelet levels, the expression of myeloid lineage marker, the incidence of Ph chromosome, the ratio of hyperdipl
ISSN:1009-2137