Role of parathyroid hormone measurement in prediction for symptomatic hypocalcaemia after total thyroidectomy

To evaluate the role of parathyroid hormone (PTH) and serum calcium in prediction for hypocalcaemia after total thyroidectomy. One hundred and sixty-five patients undergoing total or complete total thyroidectomy were reviewed retrospectively. The indications included bilateral carcinoma, undifferent...

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Published inZhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Vol. 45; no. 3; p. 217
Main Authors An, Chang-ming, Tang, Ping-zhang, Xu, Zhen-gang, Zhang, Bin, Zhang, Zong-min, Yan, Dan-gui, Li, Zheng-jiang
Format Journal Article
LanguageChinese
Published China 01.03.2010
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Calcium - blood
Child
Female
Humans
Hypocalcemia - blood
Hypocalcemia - diagnosis
Male
Middle Aged
Parathyroid Hormone - analysis
Postoperative Period
Retrospective Studies
Thyroid Neoplasms - surgery
Thyroidectomy - adverse effects
Young Adult
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Summary:To evaluate the role of parathyroid hormone (PTH) and serum calcium in prediction for hypocalcaemia after total thyroidectomy. One hundred and sixty-five patients undergoing total or complete total thyroidectomy were reviewed retrospectively. The indications included bilateral carcinoma, undifferential carcinoma, surroundings invasion, distant metastasis and huge benign lesions. Preoperative and postoperative PTH, calcium concentrations and their decline levels were compared between Jan. 2005 and May 2009. The role of PTH value and decline level predicting for symptomatic hypocalcaemia were analyzed by receiver operator characteristics (ROC) curve. After total thyroidectomy, 85 patients (51.5%) developed hypocalcemia. Symptoms were reported by 36 patients (21.8%). The mean concentration of PTH for normocalcaemia (80 cases), asymptomatic hypocalcaemia (49 cases) and symptomatic patients (36 cases) were 31.0 ng/L, 19.6 ng/L and 11.9 ng/L, respectively. The mean decline level for the three groups were 28.6%, 52.
ISSN:1673-0860