Pathological features and ultrastructure of N-methyl-N-nitrosourea (MNU)-induced thymic lymphomas in mice

The objective of study was to investigate the origin and to classify the subtype of N-methyl-N-nitrosourea (MNU)-induced thymic lymphomas in mice. Histopathologic, immunohistochemical and ultrastructural studies were performed to analyze the pathological features of the neoplasms. The results showed...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 17; no. 6; p. 1448
Main Authors Huang, Rong-Fang, Yu, Ying-Hao, Wu, Zai-Zeng, Qu, Li-Juan, Xiong, Xi-Sheng, Liu, Qing-Hong, Zeng, Lin
Format Journal Article
LanguageChinese
Published China 01.12.2009
Subjects
Animals
Female
Lymphoma - chemically induced
Lymphoma - pathology
Lymphoma - ultrastructure
Male
Methylnitrosourea - adverse effects
Mice
Mice, Inbred C57BL
Thymus Gland - pathology
Thymus Gland - ultrastructure
Thymus Neoplasms - chemically induced
Thymus Neoplasms - pathology
Thymus Neoplasms - ultrastructure
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Summary:The objective of study was to investigate the origin and to classify the subtype of N-methyl-N-nitrosourea (MNU)-induced thymic lymphomas in mice. Histopathologic, immunohistochemical and ultrastructural studies were performed to analyze the pathological features of the neoplasms. The results showed that the thymus in all cases became totally replaced by sheets of cells of the lymphoid series. All the tumors coexpressed CD3 and TdT. Transmission electron microscopic study showed the plasma membranes of malignant lymphoma cells were smooth. The nuclear profiles were usually regular, with varying percentage of convoluted nuclei. Few cell organoids were observed in cytoplasm. In conclusion, all the MNU-induced tumor classified by histopathologic, immunohistochemical and ultrastructural studies as precursor lymphoblastic lymphoma that were unquestionably related to the thymus origin and T-cell lineage.
ISSN:1009-2137