Detection of group B streptococcus in the cases died of neonatal pneumonia

From the 1970s, group B streptococci (GBS) have been widely recognized as an important pathogen in neonatal infectious disease, and it emerged as the leading cause of neonatal morbidity and mortality in the Western world. However, there are few data on the prevalence of neonatal GBS infections in Ch...

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Bibliographic Details
Published inZhonghua er ke za zhi Vol. 44; no. 11; p. 850
Main Authors Deng, Jiang-hong, Yao, Kai-hu, Hu, Hui-li, Yu, Sang-jie, Gao, Wei, Fu, Li-bing, He, Le-jian, Dmitriev, Alexander, Yang, Yong-hong
Format Journal Article
LanguageChinese
Published China 01.11.2006
Subjects
China - epidemiology
Humans
Infant, Newborn
Pneumonia, Staphylococcal - epidemiology
Prevalence
Retrospective Studies
Streptococcus agalactiae - isolation & purification
China
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Summary:From the 1970s, group B streptococci (GBS) have been widely recognized as an important pathogen in neonatal infectious disease, and it emerged as the leading cause of neonatal morbidity and mortality in the Western world. However, there are few data on the prevalence of neonatal GBS infections in China. The aim of this retrospective study was to estimate whether GBS is an important pathogen in severe neonatal pneumonia, and to develop a method for detection of GBS infections in fatal neonatal pneumonia. A total of 234 neonatal cases (0 - 28 days) died in Beijing Children's Hospital from 1953 to 2004 were enrolled in this study. They were divided into two groups. Two hundred cases diagnosed as neonatal pneumonia were assigned to study group and the remaining 34 cases died of neonatal hemolysis or surgical operation without any confirmed infectious diseases were designated as control group. Formalin-fixed, paraffin-embedded lung tissues were used as source for total genomic DNA extraction. PCR and Southern blot
ISSN:0578-1310